The recommended dose of Cialis for once daily use is 5 mg, taken at approximately the same time every day. cialis 5 mg tablet Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. Tadalafil inhibits PDE5. Because sexual stimulation is required to initiate the local release of nitric oxide, the inhibition of PDE5 by tadalafil has no effect in the absence of sexual stimulation.
Physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity. Therefore, treatment for erectile dysfunction, including Levitra, should not be used in men for whom sexual activity is not recommended because of their underlying cardiovascular status.The mean profiles of the change from baseline in standing systolic blood pressure in subjects treated with doxazosin in combination with 50 mg Viagra or matching placebo are shown in Figure 3.
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LEVITRA has been shown to be effective in men over the age of 18 years who have erectile dysfunction, including men with diabetes or who have undergone prostatectomy.For more information about the various options for treating erectile dysfunction, check out “Drugs and Devices for Erectile Dysfunction.”
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Results of these studies showed that Levitra did not alter the total treadmill exercise time compared to placebo (10 mg Levitra vs. placebo: 433±109 and 426±105 seconds, respectively; 20 mg Levitra vs. placebo: 414±114 and 411±124 seconds, respectively). The total time to angina was not altered by Levitra when compared to placebo (10 mg Levitra vs. placebo: 291±123 and 292±110 seconds; 20 mg Levitra vs. placebo: 354±137 and 347±143 seconds, respectively). The total time to 1 mm or greater ST-segment depression was similar to placebo in both the 10 mg and the 20 mg Levitra groups (10 mg Levitra vs. placebo: 380±108 and 334±108 seconds; 20 mg Levitra vs. placebo: 364±101 and 366±105 seconds, respectively).Blood pressure was measured manually pre-dose at two time points (-30 and -15 minutes) and then at 1, 2, 3, 4, 5, 6, 7, 8, 10, 12 and 24 hours post dose on the first day of each doxazosin dose, (1 mg, 2 mg, 4 mg), as well as on the seventh day of 4 mg doxazosin administration.Active Ingredient/Active Moiety
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